
709 F.Supp.2d 1375 (2010)
In re AMBULATORY PAIN PUMP-CHONDROLYSIS PRODUCTS LIABILITY LITIGATION.
MDL No. 2139.
United States Judicial Panel on Multidistrict Litigation.
May 5, 2010.
Before KATHRYN H. VRATIL, Acting Chairman, JOHN G. HEYBURN II, Chairman[*], ROBERT L. MILLER, JR.[*], DAVID R. HANSEN, W. ROYAL FURGESON, JR., FRANK C. DAMRELL, JR. and DAVID G. TRAGER[*], Judges of the Panel.

ORDER DENYING TRANSFER
KATHRYN H. VRATIL, Acting Chairman.
Before the entire Panel[*]: Plaintiffs in one action pending in the District of Minnesota and two actions pending in the Southern District of Ohio have moved, pursuant to 28 U.S.C. § 1407, to centralize this litigation in the District of Minnesota. The litigation currently consists of the 102 actions listed on Schedule A.[1] Movants request *1376 that the Panel exclude from centralization an additional twelve actions (seven Eastern District of Kentucky actions and five Southern District of Ohio actions), on the ground that they are too procedurally advanced to benefit from centralization.

I.
Most responding plaintiffs support centralization, but some, like movants, request exclusion of certain actions from centralized proceedings. For example, the self-described "Oregon/MultiState Plaintiffs" (plaintiffs in 60 constituent actions and fourteen potential tag-along actions) ask that the three oldest District of Oregon actions be excluded from centralization, contending that those actions are nearly trial-ready. Similarly, plaintiffs in Southern District of Ohio West argue that their action is essentially as advanced as the five other actions pending in that district which movants seek to have excluded from centralization. Plaintiff in District of Arizona Lopez (a/k/a Miller) opposes centralization as to the several pending actions in that district against I-Flow Corp. (I-Flow), on the ground that the presiding judge has already consolidated those actions for pretrial purposes.
Responding plaintiffs disagree as to an appropriate transferee district. Plaintiffs in District of Minnesota Cramlet and District of Utah Creech support selection of the District of Minnesota. The Oregon/Multi-State Plaintiffs favor the District of Oregon, as do plaintiffs in five Eastern District of Pennsylvania actions. Plaintiffs in seven constituent actions and seven potential tag-along actions advocate the Eastern District of New York (or in the alternative, the District of New Jersey, the District of Oregon, or the District of Minnesotain that order).
Responding defendants, for the most part, oppose centralization. These defendants include DJO, LLC; DJO, Inc.; DonJoy, Inc.; D.J. Orthopedics, Inc.; Reable Therapeutics, Inc.; Reable Therapeutics, L.L.C.; Pacific Medical, Inc.; Stryker Corp.; Stryker Sales Corp.; Breg, Inc.; Zimmer, Inc.; Zimmer Holdings, Inc.; AstraZeneca PLC; AstraZeneca Pharmaceuticals LP; AstraZeneca LP; Zeneca Holdings Inc.; APP Pharmaceuticals, LLC; APP Pharmaceuticals, Inc.; Abraxis BioScience, LLC; Abraxis BioScience, Inc.; Hospira, Inc.; Abbott Laboratories; Advanced Technology of Kentucky, Inc. (d/b/a Advanced Technologies, Inc.); and Smith and Nephew. If the Panel orders centralization over their objections, then most of these defendants, to the extent they express a preference, support selection of the District of Colorado as transferee district.
Some defendants, however, support the Section 1407 motion, either in part or in whole. I-Flow argues that the Panel should centralize, without exception, all actions involving alleged injury to the shoulder (as opposed to the knee or ankle), but only for pretrial proceedings on the issues of general causation and product identification, after which, in I-Flow's view, the actions would be remanded to their respective transferor courts. McKinley Medical, LLC, Curlin Medical Inc., and Moog Inc., by contrast, support centralization of all actions, including those few involving alleged injury to the knee or ankle. SMI Liquidating, Inc. (f/k/a Sorenson Medical, Inc.), Sorenson Medical Products, Inc., Sorenson Development Inc., SDI Residual Assets LLC, and James Lee Sorenson (collectively the Sorenson Defendants) state that they are not opposed to centralization, so long as no actionsespecially those pending in the Eastern District of Kentuckyare carved out of centralized proceedings. With respect to a transferee district, I-Flow's first choice is the Northern District of Illinois, but the McKinley, Curlin, and Moog defendants and the Sorenson Defendants favor the District of Colorado.


*1377 II.
This litigation comes before us for a second time. In August 2008, we denied centralization in MDL No. 1966, In re: Shoulder Pain Pump-Chondrolysis Products Liability Litigation. That docket involved a total of thirteen actions (including several of the 102 actions in this docket), as well as eighteen potential tag-along actions. Moving plaintiffs sought centralization in the District of Oregon, and responding plaintiffs supported centralization in either that or another district. All responding defendants, however, opposed centralization.
In our order denying the Section 1407 motion in MDL No. 1966, we stated:
Although these personal injury actions have some commonality as to whether shoulder pain pumps and/or the anesthetic drugs used in those pumps cause glenohumeral chondrolysis, an indeterminate number of different pain pumps made by different manufacturers are at issue, as are different anesthetic drugs made by different pharmaceutical companies. Moreover, not all of the thirteen constituent actions involve pharmaceutical company defendants, and many defendants are sued only in a minority of those actions. The proponents of centralization have not convinced us that the efficiencies that might be gained by centralization would not be overwhelmed by the multiple individualized issues (including ones of liability and causation) that these actions appear to present. The parties can avail themselves of alternatives to Section 1407 transfer to minimize whatever possibilities there might be of duplicative discovery and/or inconsistent pretrial rulings.
In re: Shoulder Pain PumpChondrolysis Products Liability Litigation, 571 F.Supp.2d 1367, 1368 (J.P.M.L.2008) (footnotes omitted).

III.
On the basis of the papers filed and hearing session held, we will deny the Section 1407 motion. Like the actions in MDL No. 1966, the actions in this docket share allegations that ambulatory pain pumps and/or the anesthetic drugs used in those pumps cause chondrolysis (i.e., necrosis and destruction of cartilage). Although the number of related actions has certainly grown, the issues that weighed against centralization in that earlier docket remain. An indeterminate number of different pain pumps made by different manufacturers are still at issue, as are different anesthetics made by different pharmaceutical companies. Most, if not all, defendants are named in only a minority of actions; and several defendants are named in but a handful of actions.[2] Many actions involve no anesthetic manufacturers at all.
Also as with the actions in MDL No. 1966, individual issues of causation and liability continue to appear to predominate, and remain likely to overwhelm any efficiencies that might be gained by centralization. According to defendants, pain pumps come in different sizes and designs, with differing volume, duration, and flow capacities. The same anesthetic was not used in all surgeries. Plaintiffs have different medical histories (indeed, some have undergone more than one surgery involving a pain pump).[3]
*1378 Finally, the constituent actions are at widely varying procedural stages. In many, fact discovery is either over or nearly over. The record shows that expert discovery is underway or has been completed in a number of actions.[4] Although movants and other plaintiffs favoring centralization argue that defendants have stymied their efforts to streamline discovery, that argument is undercut by the multiple requests to exclude certain actions on the ground that they are too advanced to warrant inclusion in an MDL. Given all these circumstances, we are still unconvinced that centralization would serve the convenience of the parties or promote the just and efficient conduct of the litigation, taken as a whole.
IT IS THEREFORE ORDERED that, pursuant to 28 U.S.C. § 1407, the motion for centralization is denied.

SCHEDULE A
MDL No. 2139  IN RE: AMBULATORY PAIN PUMP-CHONDROLYSIS PRODUCTS LIABILITY LITIGATION
Northern District of Alabama

Paul W. Westbrook v. DJO, Inc., et al., C.A. No. 5:08-263
District of Arizona

Jessica N. Lopez v. I-Flow, Inc., et al., C.A. No. 2:08-1063

Cole D. Chapman v. DJO, LLC, et al., C.A. No. 2:08-1064

Andrew Gilmore, et al. v. DJO, Inc., et al., C.A. No. 2:08-1252

Matthew B. Goldstein v. I-Flow, Inc., et al., C.A. No. 2:08-1859

Julie A. Eggler v. I-Flow, Inc., et al., C.A. No. 2:09-40

Dianne L. Engle v. Stryker Corp., et al., C.A. No. 2:09-41

Anthony B. Hannigan v. I-Flow, Inc., et al., C.A. No. 2:09-42

Linda Relkin, et al. v. I-Flow, Inc., et al., C.A. No. 2:09-44

Duane Hjelt v. I-Flow, Inc., et al., C.A. No. 2:09-64

Laura E. Ashworth, et al. v. I-Flow Corp., et al., C.A. No. 2:09-721

Sheri L. Patrick, et al. v. I-Flow Corp., et al., C.A. No. 2:09-723

Kevin Hines, et al. v. I-Flow Corp., et al., C.A. No. 2:09-2189

Tyler Benson v. Stryker Corp., C.A. No. 4:08-351

Erin Whitney Grandy Moore v. Breg, Inc., C.A. No. 4:09-27

Ray Wilson v. Stryker Corp., et al., C.A. No. 4:09-539
Central District of California

Kent J. Klawer v. SMI Liquidating, Inc., et al., C.A. No. 2:08-4991
Eastern District of California

Adam Phillippi, et al. v. AstraZeneca Pharmaceuticals, LP, et al., C.A. No. 2:08-2445

Terri Lynn Todd v. Stryker Corp., et al., C.A. No. 2:09-1509

Julie M. Combs, et al. v. Stryker Corp., et al., C.A. No. 2:09-2018
District of Colorado

Stacey Ann Hansen v. DJO, Inc., et al., C.A. No. 1:08-365

*1379 Vinton Theiss, et al. v. I-Flow, Inc., et al., C.A. No. 1:08-2606

Cressa Sullivan v. I-Flow Corp., et al., C.A. No. 1:08-2648

Christina Pavelko v. Breg, Inc., C.A. No. 1:09-1461

Kevin Hoy v. I-Flow Corp., et al., C.A. No. 1:09-2580
Middle District of Florida

Davis A. Prickett v. Stryker Corp., et al., C.A. No. 8:09-992
Northern District of Florida

Suzette Martin, et al. v. I-Flow Corp., C.A. No. 3:08-127
Southern District of Indiana

Joseph D. Essex, et al. v. I-Flow Corp., C.A. No. 1:09-1380
Western District of Kentucky

Kris Prather v. Stryker Corp., et al., C.A. No. 3:09-573
District of Minnesota

Shari Martinac, et al. v. I-Flow Corp., et al., C.A. No. 0:08-5035

Jaimee Fougner v. I-Flow Corp., et al., C.A. No. 0:08-5157

Katie Todd, et al. v. I-Flow Corp., et al., C.A. No. 0:08-6178

Nicole Stapleton Foley, et al. v. I-Flow Corp., et al., C.A. No. 0:08-6197

Kathy Ivey, et al. v. McKinley Medical, LLC, et al., C.A. No. 0:08-6407

April M. Murrell, et al. v. Zimmer, Inc., et al., C.A. No. 0:09-757

Jeanie A. Hendricks, et al. v. DJO, LLC, et al., C.A. No. 0:09-931

Anita McGinness, et al. v. DJO, LLC, et al., C.A. No. 0:09-1174

Robert L. Huggins, et al. v. Stryker Sales Corp., et al., C.A. No. 0:09-1250

Mary J. Block v. McKinley Medical, LLC, et al., C.A. No. 0:09-1332

Daniel Krizan v. DJO, LLC, et al., C.A. No. 0:09-1341

Craig R. Anderson v. DJO, LLC, et al., C.A. No. 0:09-1673

Wesley Crawford v. DJO, LLC, et al., C.A. No. 0:09-1674

Joel V. Haymes v. DJO, LLC, et al., C.A. No. 0:09-1675

Henry Wheeler v. Breg, Inc., et al., C.A. No. 0:09-1692

Sylvester Ishmael v. DJO, LLC, et al., C.A. No. 0:09-1693

Joshua H. Voller v. I-Flow Corp., et al., C.A. No. 0:09-1906

James Forslund v. Stryker Corp., et al., C.A. No. 0:09-2134

Tara R. Davis v. I-Flow Corp., et al., C.A. No. 0:09-2504

Marilyn D. Reynolds v. DJO, LLC, et al., C.A. No. 0:09-2706

Gina K. Bass v. DJO, LLC, et al., C.A. No. 0:09-2707

Jennifer E. Prettyman v. Stryker Sales Corp., et al., C.A. No. 0:09-2794

Michael B. Bonander v. Breg, Inc., et al., C.A. No. 0:09-2795

Thomas H. Stiltner v. Stryker Corp., et al., C.A. No. 0:09-2796
District of Minnesota (Continued)

Randall D. Collins v. I-Flow Corp., et al., C.A. No. 0:09-2816

Carlos R. Flores-Espinoza v. Breg, Inc., et al., C.A. No. 0:09-2817

Christi L. Fielding v. Stryker Sales Corp., et al., C.A. No. 0:09-2865

Susan A. Newman v. Stryker Sales Corp., et al., C.A. No. 0:09-2866

Katherine M. Baker v. DJO, LLC, et al., C.A. No. 0:09-2898

Jeffrey L. Quibell v. Stryker Sales Corp., et al., C.A. No. 0:09-2899

*1380 Wesley A. Kay v. I-Flow Corp., et al., C.A. No. 0:09-3012

Adam J. Cramlet v. I-Flow Corp., et al., C.A. No. 0:09-3169
Southern District of Mississippi

Darryl Campbell v. I-Flow Corp., C.A. No. 1:08-168
District of Nevada

Rebecca Graham, et al. v. I-Flow Corp., et al., C.A. No. 2:09-531

Jack Frobes, et al. v. Stryker Corp., et al., C.A. No. 3:09-554
District of New Jersey

Mark Yodice v. Stryker Corp., et al., C.A. No. 3:09-3896
District of New Mexico

Sherrie Bailey v. I-Flow Corp., et al., C.A. No. 1:09-531
Eastern District of North Carolina

Sarah E. Atwell v. DJO, Inc., et al., C.A. No. 5:08-346

Corissa R. Allison, et al. v. DJO, Inc., et al., C.A. No. 5:08-549
Northern District of Ohio

Deborah L. Mayle, et al. v. Stryker Corp., et al., C.A. No. 5:09-1991

Allen Crisp v. Stryker Corp., et al., C.A. No. 5:09-2212
Southern District of Ohio

Rachel Krumpelbeck v. Breg, Inc., et al., C.A. No. 1:09-91

Amy West, et al. v. I-Flow Corp., C.A. No. 1:09-98

Willie Miller v. Stryker Corp., et al., C.A. No. 1:09-588

Brittany Hamilton, et al. v. Breg, Inc., et al., C.A. No. 2:09-146

Kaid C. Musgrave, et al. v. Breg, Inc., et al., C.A. No. 2:09-1039

Wesley Stichweh v. Stryker Corp., et al., C.A. No. 3:08-370
Western District of Oklahoma

Joe C. Smock v. I-Flow Corp., C.A. No. 5:08-1077
District of Oregon

Christina McClellan v. I-Flow Corp., et al., C.A. No. 6:07-1309

Gregory Turner, et al. v. Stryker Corp., et al., C.A. No. 6:07-1310

Gordon J. Addis v. McKinley Medical, LLC, et al., C.A. No. 6:07-1318

Caleb Huggins, et al. v. Stryker Corp., et al., C.A. No. 6:07-1671

Danny E. Arvidson, et al. v. DJO, LLC, et al., C.A. No. 6:08-478

John Eric Butler v. Stryker Corp., et al., C.A. No. 6:08-588

Joann Stoeher v. I-Flow Corp., C.A. No. 6:08-1012

Donna Snodgrass, et al. v. I-Flow Corp., et al., C.A. No. 6:08-1387

Eric J. Schoenborn, et al. v. Stryker Corp., et al., C.A. No. 6:08-1419

Elizabeth D. Cronin v. I-Flow Corp., C.A. No. 6:09-146

Ivy Lee Y. Natividad, et al. v. Stryker Corp., et al., C.A. No. 6:09-378
Eastern District of Pennsylvania

Derek Giangiulio v. I-Flow Corp., C.A. No. 2:08-287

Glen Gore, et al. v. Stryker Corp., et al., C.A. No. 2:09-2987

Allison Foret v. Stryker Corp., et al., C.A. No. 2:09-2991

Nathan Geesey v. Stryker Corp., et al., C.A. No. 5:09-2988
Western District of Pennsylvania

Donna J. Lawton, et al. v. Advanced Infusion, Inc., et al., C.A. No. 2:09-1197

*1381 District of South Dakota


Marcus J. Suhn v. Breg, Inc., et al., C.A. No. 4:08-4190

Kelly J. Koch v. Breg, Inc., et al., C.A. No. 4:08-4193
Eastern District of Tennessee

Terry A. Hill v. Stryker Corp., et al., C.A. No. 3:08-295

Randi C. Brostean v. Stryker Corp., et al., C.A. No. 3:08-406
Middle District of Tennessee

Andrew Scott Rodriguez v. Stryker Corp., et al., C.A. No. 2:08-124
Western District of Tennessee

Kimberly Dawn Evans, et al. v. DJO, LLC, et al., C.A. No. 2:09-2515
District of Utah

Erika Creech, et al. v. Stryker Corp., et al., C.A. No. 1:07-22

Amanda Bennett v. Stryker Corp., et al., C.A. No. 2:08-937

Ryan Goodrich, et al. v. I-Flow Corp., et al., C.A. No. 2:09-269
NOTES
[*]  Judges Heyburn, Miller, and Trager took no part in the disposition of this matter.
[1]  There are more than 70 additional related actions pending in various districts.
[2]  For example, the AstraZeneca entities are defendants in fewer than twenty of the constituent actions; Breg, Inc., is a defendant in fewer than fifteen of the actions; Pacific Medical, Inc., is a defendant in only four actions; and the Zimmer defendants are named in only one action.
[3]  Although proponents of centralization argue that the scientific data and clinical studies demonstrate that the continuous infusion of anesthetic into the joint space destroys cartilage, the record indicates that the science is, in fact, not so certain. In a November 2009 bulletin concerning 35 reports of chondrolysis in patients who received such infusions, the FDA stated: "It is not known which specific factor or combination of factors contributed to the development of chondrolysis in these cases."
[4]  In several of the District of Oregon actions, for example, the court conducted a Daubert hearing over two days last November, and resumed that hearing this past month.
