598 F.2d 637
13 ERC 1193, 9 Envtl. L. Rep. 20,609
BASF WYANDOTTE CORP. et al., Petitioners,v.Douglas M. COSTLE, as Administrator, EnvironmentalProtection Agency, Respondent.E. I. du PONT de NEMOURS & CO. et al., Petitioners,v.Douglas M. COSTLE, as Administrator, EnvironmentalProtection Agency, Respondent.MONSANTO COMPANY, Petitioner,v.Douglas M. COSTLE, as Administrator, EnvironmentalProtection Agency, Respondent.DOW CHEMICAL COMPANY, Petitioner,v.Douglas M. COSTLE, as Administrator, EnvironmentalProtection Agency, Respondent.MONSANTO COMPANY, Petitioner,v.Douglas M. COSTLE, as Administrator, EnvironmentalProtection Agency, Respondent.DOW CHEMICAL COMPANY, Petitioner,v.Douglas M. COSTLE, as Administrator, EnvironmentalProtection Agency, Respondent.E. I. du PONT de NEMOURS & CO. et al., Petitioners,v.Douglas M. COSTLE, as Administrator, EnvironmentalProtection Agency, Respondent.ELI LILLY AND COMPANY, Petitioner,v.Douglas M. COSTLE, as Administrator, EnvironmentalProtection Agency, Respondent.National Agricultural Chemicals Association, Intervenor.
Nos. 77-1042, 77-1059, 77-1085, 77-1153, 78-1417, 78-1428,78-1454 and 78-1462.
United States Court of Appeals,First Circuit.
Argued Jan. 3, 1979.Decided May 7, 1979.

Douglas E. Kliever, Washington, D. C., with whom Robert C. Barnard, Charles F. Lettow, John S. Magney, and Cleary, Gottlieb, Steen & Hamilton, Washington, D. C., were on brief, for petitioners in Nos. 77-1042, 77-1059, 77-1085, 78-1417, 78-1454, and 78-1462.
J. D. Fleming, Jr., Atlanta, Ga., with whom D. Robert Cumming, Jr., John H. Fleming, and Sutherland, Asbill & Brennan, Atlanta, Ga., were on brief, for petitioner in Nos. 77-1153 and 78-1428.
Robert L. Ackerly, Washington, D. C., with whom Richard A. Flye, Sellers, Conner & Cuneo, Washington, D. C., and Paul M. Siskind, Boston, Mass., were on brief, for intervenor.
Paul M. Kaplow, Atty., Dept. of Justice, and Colburn T. Cherney, Atty., Environmental Protection Agency, with whom James A. Rogers, Associate Gen. Counsel, Steven Schatzow, Deputy Associate Gen. Counsel, Environmental Protection Agency, James W. Moorman, Asst. Atty. Gen., and Angus MacBeth, Washington, D. C., were on brief, for respondent.
Before COFFIN, Chief Judge, BOWNES, Circuit Judge, MAZZONE,* District Judge.
COFFIN, Chief Judge.


1
These consolidated petitions have been brought by eleven manufacturers of pesticides1 against the respondent, the Administrator of the Environmental Protection Agency (EPA or Agency), seeking review of regulations governing the discharge of pollutants by the pesticide industry.  40 C.F.R. Part 455, 43 Fed.Reg. 17776 and 43 Fed.Reg. 44845 (1978).  An industry organization, the National Agricultural Chemical Association (NACA), has intervened.  The Federal Water Pollution Control Act states as a "national goal that the discharge of pollutants into the navigable waters be eliminated by 1985."  33 U.S.C. § 1251(a)(1).  These regulations are promulgated in response to Congress' direction that the Administrator provide guidelines for the effluent reduction possible through implementation of the "best practicable control technology currently available".  33 U.S.C. §§ 1311(b)(1)(A) and 1314(b)(1).2


2
In 1974 the Agency hired an outside contractor, Roy F. Weston, Inc.  (Weston), to analyze the industry.  Weston submitted its final report in December of 1975.  In early 1976 EPA hired a second contractor, Environmental Science and Engineering, Inc.  (ESE), to evaluate Weston's work.  ESE determined that Weston's work needed improvement and undertook its own study of the industry.  In late 1976 EPA published interim final regulations that were immediately effective, but on which EPA invited public comment.  41 Fed.Reg. 48087 (1976).  An interim development document and an economic analysis explaining the derivation of the interim regulations were also released.


3
In the months following publication of the interim regulations EPA received comments on many issues raised by the regulations.  EPA also collected additional data and conducted further research.  In early 1978 the final regulations were published, 43 Fed.Reg. 17776 (1978), as were a final development document and economic analysis.  The final regulations differed from the interim regulations in a number of significant ways.  The one principally relevant in this case is that EPA finally subdivided the industry into three subcategories: (1) Organic Pesticide Chemicals Manufacturing; (2) Metallo-Organic Pesticide Chemicals Manufacturing; and (3) Pesticide Chemicals Formulating and Packaging.  In the interim regulations the organic pesticide subcategory had been further divided into three subcategories.  For the second and third final subcategories the regulations permit "no discharge of process waste water pollutants into navigable waters."  40 C.F.R. §§ 455.32 and 455.42.  For the first subcategory, 40 C.F.R. § 455.22 limits the pounds or kilograms of chemical oxygen demand (COD), biological oxygen demand (BOD), total suspended solids, and pesticide chemicals that a plant may discharge per thousand pounds or kilograms of pesticide produced during any one day or any 30 consecutive days.  The levels set are lower than the levels set by the interims for some producers and higher for others.  Also the pH level (the relative acidity or alkalinity) of the effluent must be within a set range.


4
After the final regulations issued, one of the petitioners filed a motion for reconsideration alleging, among other things, that analytical techniques were not available to detect many pesticides at the levels stated in the regulations.  EPA reexamined the record and discovered that some measurement methods that EPA thought were available might not be reliable.  Accordingly, EPA amended the regulations so that the pesticide content of process waste water would be limited for the producers of only 49 out of several hundred pesticides.  43 Fed.Reg. 44845, 44856 (1978).


5
The first petition for review challenged the interim final regulations.  When the final regulations were published we granted permission to amend so as to include review of the finals.  BASF Wyandotte Corp. v. Costle, 582 F.2d 108 (1st Cir. 1978).  Subsequently the petitions for review filed in other circuits were transferred to this circuit.  The consolidated petitions assert several procedural and substantive errors in the regulations and their promulgation.

I. Organic Pesticide Manufacturing
A. Administrative Procedure Act Compliance

6
Petitioners' first complaint is that EPA failed to comply with the requirements of the Administrative Procedure Act in that the final regulations were so different from the interim final regulations that the interims were not notice of "either the terms or substance of the proposed rule or a description of the subjects and issues involved."  5 U.S.C. § 553(b)(3).  This requirement is a critical one because it supports the assumption we make with regard to EPA's substantive decisions that those decisions are in fact the product of informed, expert reasoning tested by exposure to diverse public comment.  Though our review of an agency's final decision is relatively narrow, we must be strict in reviewing an agency's compliance with procedural rules.  See Weyerhaeuser Co. v. Costle, 590 F.2d 1011, 1027-1028 (D.C. Cir. 1978).


7
In this case EPA issued interim final regulations and sought comments on them.  Industry representatives, government agencies, and others submitted voluminous comments on many aspects of the interim regulations.  It is clear that EPA gave careful consideration to these comments.  The Agency summarized the public comment, together with the Agency responses in the prologue to the final regulations.  43 Fed.Reg. 17781-85 (1978).  The Agency accepted several suggestions made in comments critical of the interim regulations.  For instance, EPA deleted some parameters by which the interim regulations controlled discharges,3 abandoned use of COD/BOD ratios to supplement raw waste load data, and tried certain statistical tests proposed by commenters.  EPA further demonstrated its openness to comments by eliminating, as we have noted, pesticide discharge limits for all but 49 chemicals in response to information received after the final regulations were printed.


8
The procedural rules were meant to ensure meaningful public participation in agency proceedings, not to be a straitjacket for agencies.  An agency's promulgation of proposed rules is not a guarantee that those rules will be changed only in the ways the targets of the rules suggest.  "The requirement of submission of a proposed rule for comment does not automatically generate a new opportunity for comment merely because the rule promulgated by the agency differs from the rule it proposed, partly at least in response to submissions."  International Harvester Co. v. Ruckelshaus, 155 U.S.App.D.C. 411, 428, 478 F.2d 615, 632 (1973); Weyerhaeuser Co. v. Costle, supra, at 1031; American Frozen Food Institute v. Train, 176 U.S.App.D.C. 105, 132, 539 F.2d 107, 134 (1976).  Even substantial changes in the original plan may be made so long as they are "in character with the original scheme" and "a logical outgrowth" of the notice and comment already given.  South Terminal Corp. v. EPA, 504 F.2d 646, 658, 659 (1st Cir. 1974).


9
The essential inquiry is whether the commenters have had a fair opportunity to present their views on the contents of the final plan.4  We must be satisfied, in other words, that given a new opportunity to comment, commenters would not have their first occasion to offer new and different criticisms which the Agency might find convincing.  Weyerhaeuser, at 1031.  Thus, where the final rules "are the result of a complex mix of controversial and uncommented upon data and calculations", remand may be in order.  Id.  Similarly, where the Agency adds a new pollution control parameter without giving notice of intention to do so or receiving comments, there must be a remand to allow public comment.  American Frozen Food Institute, supra, 176 U.S.App.D.C. at 133, 539 F.2d at 135.  The question, however, always requires careful consideration on a case-by-case basis.


10
The first and principal change complained of is the Agency's decision to merge the first three interim subcategories5 into a single Organic Pesticide Chemicals Manufacturing subcategory.6  So far as the record discloses, petitioners were not aware of this change until the final regulations were promulgated and the time for comment had expired.  EPA consolidated the former subcategories because it "recognized certain ambiguities were present in its subcategorization based on chemical structure.  Many pesticides contain more than one functional group . . .  and do not fit the former subcategorization scheme."  43 Fed.Reg. 17777 (1978).  Consequently, "and in response to industry comments", EPA undertook further research and found that "the quantities of pollutants in the effluents of those plants with the properly operated model technologies installed were similar regardless of the organic pesticide chemicals manufactured.  The Agency . . .  therefore concluded that the waste waters of all organic pesticide chemicals can be treated or controlled to the levels documented.  . . .  Thus, the final regulations do not differentiate among halogenated organic, organo-phosphorus, or organo-nitrogen pesticide chemicals."  Id.


11
The industry comments were almost unanimous in condemning the three original subcategories both for being internally inconsistent and insufficiently differentiated from the other categories.7  Comments presented statistical tests of EPA's data, purporting to show that the subcategories were not distinguishable from each other.8  Comments also pointed to the inclusion of very different compounds within particular subcategories.  The comments made a strong case against use of the interim subcategories, and EPA decided that the criticism was persuasive.  It follows that EPA had to decide on an alternative unless it was to abandon regulation of the pesticide industry.  Industry's preference was clear.  They wanted EPA to expand the number of subcategories.  They are now aggrieved because EPA accepted their criticism of the original subcategories but chose a different solution, collapsing rather than expanding them.  Petitioners suggest that EPA's response took them entirely by surprise and that EPA had somehow indicated that the only issue for comments would be whether three subcategories were enough or there should be more.


12
Neither suggestion is grounds for remand.  It should be clear to commenters when they criticize a regulatory scheme that if the agency accepts those criticisms, a new scheme will be substituted.  The commenters cannot claim they had no notice to propose and discuss alternatives.  And in fact they did so, suggesting a number of new approaches based on different ways to subcategorize the industry.  In fact, at least one commenter recognized that if the existing scheme was not defensible, one alternative would be to abandon subcategories.  This commenter, also a petitioner, Monsanto, wrote:


13
"It is our belief that additional partitioning of chemical groups based on the above environmental impact factors must be accomplished If the Agency intends to pursue the subcategorization approach."  App. at 1905.  (Emphasis added.)


14
Clearly Monsanto realized that the Agency would have to consider alternatives and was not finally committed to subcategories.  Moreover, Monsanto's response indicates that the Agency had not misled petitioners into thinking that they need only state views on the desirability of more subcategories rather than the undesirability of fewer.


15
Another repeated call of the industry commenters was that the subcategories should be more equitably treated because the record did not support the significantly different guideline limits assigned to the different subcategories.9  They should have realized that these criticisms, if accepted, could be resolved, among other ways, by applying the same limits to all organic pesticides.  Again, though EPA's solution was not the one for which industry argued, it was suggested by and, in part, a logical outgrowth of industry's comments.  They cannot now complain because they misread the regulatory waters, incorrectly anticipated how EPA would react to their criticisms, and, consequently, submitted comments that left some things unsaid.


16
Not only do we think that petitioners had fair notice that consolidation of subcategories was an issue to comment upon, but we cannot think how their comments would have differed fundamentally if they had known what EPA would do.  Though they would have had a different proposition against which to argue, their proposed solutions would, presumably, have been the same for the same reasons.  They might have responded in greater volume or more vociferously, but they have not shown us that the content of their criticisms would have been different to the point that they would have stood a better chance of convincing the Agency to use more subcategories.  In short, they had a fair opportunity to present their views on how the industry ought to be subcategorized.  Their real complaint is that EPA rejected those views.


17
For the same reasons, we do not think EPA was obligated to provide further opportunity to comment on "its decision to limit the regulations to those pesticides for which there are reliable analytical methods" or "its determination that all pesticides can be treated to a single level regardless of differences in treatability of particular pesticides".  To the extent the latter differs from the decision to consolidate categories, it was clearly signalled in the interim regulations.  As the commenters pointed out, the interim subcategories were based on physical structure and each included chemicals of diverse treatability.  The industry's comments plainly suggested that treatability ought to be taken into account.10  Similarly, as to the former, the interim regulations applied a limit on the discharge of total pesticides to all manufacturers of pesticides.  Any manufacturer that had reason to believe its pesticides could not be detected at the guideline limit had the opportunity to ask the Agency to change its regulations as to any particular pesticide or as to all pesticides.  The Agency's receptiveness to such comments is indicated by the very decision attacked, its elimination of limits as to all but 49 organic pesticides when confronted with information showing that others were not reliably detectible.  There was no lack of notice as to these subjects.


18
The last point we must address is a different and more difficult one.  One of EPA's justifications for consolidating the subcategories and for reducing the discharge limits for many pesticides was the conclusion, based in part on "additional raw waste load and treatment data, and additional pilot plant and laboratory data" that "the waste waters of all organic pesticide chemicals can be treated or controlled to the levels documented in the Agency's data base."   43 Fed.Reg. at 17777.  The BASF petitioners argue that since the EPA's conclusions were premised on "new data on the applicability and effectiveness of treatment by activated carbon and by hydrolysis" EPA should have entertained a new round of comments.11


19
Certainly nothing is more important than the bottom line numbers which determine whether individual plants are or are not in compliance with the regulations.  The data that an agency has used to set proposed limits obviously should be subject to public comment if possible.  Indeed, as another circuit court has noted, factual matters "are especially subject to verification through the notice and comment process and less acceptably removed therefrom."  Weyerhaeuser, slip op. at 1030 n. 26.


20
This does not mean, however, that any new numbers gathered after publication of proposed regulations must be submitted for comment.  It is perfectly predictable that new data will come in during the comment period, either submitted by the public with comments or collected by the agency in a continuing effort to give the regulations a more accurate foundation.  The agency should be encouraged to use such information in its final calculations without thereby risking the requirement of a new comment period.  Though in this instance the new information is in the form of numbers, our inquiry is no different than where the new information takes any other form.  We must decide whether using new data that reduced the effluent limits for many of the producers deprived the public of a fair opportunity to present views on the final data base.  If data used and disclosed for the interim regulations presented the issues for comment, then there is no need to seek new comment even though significant quantitative differences result.


21
We conclude that EPA was within the law.  The final regulations set the pesticide discharge limit on the basis of data from nine plants with recommended pesticide removal technology.  Seven of these nine plants were mentioned in the interim development document as forming the basis for or supporting the limits set by the interim regulations.12  These seven plants accounted for about 82 per cent of the data points used to determine the final limits.  Their products, treatment systems, and raw waste load were all discussed in detail in the interim development document, as was what was known of the content of their waste water discharges.  On the strength of what was disclosed in the interim development document, therefore, petitioners could have commented on the applicability of these plants' treatment systems to other plants, and on the importance of different processes, products, and volumes.


22
More importantly, the interim development document disclosed the method by which EPA calculated the limits.  This methodology was substantially the same for the interim and final regulations.  EPA afforded petitioners the chance to make the most meaningful possible contribution to the regulatory process because the petitioners could use the information to collect data at their own plants, analyze it, and submit it to EPA.  Not only would such input have guaranteed that EPA would be acting on the most complete data base possible, but it would have guaranteed that the special problems faced by each petitioner would have been taken account of by EPA and contributed to the resulting limitations.13  Petitioners knew the role that every available piece of data would play in generating the limits.  EPA used all the data supplied to it.


23
As to these seven plants, petitioners knew all they needed to know in order to make a meaningful contribution to the regulatory process and a meaningful comment on the regulations proposed.  All they did not know was what the actual raw numbers would be.  While these numbers were certainly crucial in setting the limits and of obviously great interest to the petitioners, we are not convinced that knowing them would have significantly improved petitioners' opportunity to comment.  They would have had a different numerical target for their many complaints about the limits set, but that would not have greatly advanced their ability to make positive contributions to the process by criticizing from their own knowledge the treatment technologies recommended, the success they could anticipate by implementing those technologies, and the analytical and statistical methodology EPA used to turn the raw numbers into effluent limits.  In short, in this case, we think it was far more important for EPA to solicit comments on how it intended to collect and use data than on the data itself.14


24
Regulatory targets have no guarantee that proposed effluent limits, which they are capable of meeting, will stay the same.  The purpose of soliciting comments is to be able to make informed changes, and those interest groups preferring looser limits are not the only ones whose comments are solicited.  Other governmental agencies or public environmental protection groups are free to seek whatever changes they feel desirable, and the EPA is free to adopt those suggestions if it is persuaded.


25
As for the two plants that did not contribute to the generation of the interim limits, the same arguments apply in part.  All they added to the process were more numbers to be used in the same way as the other numbers.  Their treatment technologies are not markedly different from the others and conform to EPA's fully disclosed model technology.15  Moreover, were these two plants omitted from consideration the final limits would be more stringent since both of these plants discharge more than the allowable amount of pollutants.16

B. EPA's Scientific Methodology

26
The BASF petitioners have tenaciously attacked the methodology and data used by ESE in calculating the final effluent limitations for organic pesticides.  If ESE's work is not reliable, then the final limitations cannot stand.  Partly because of a belated turnover of some 2000 pages of laboratory documents all of those used by ESE for this rulemaking proceeding we have been faced with three rounds of briefing memoranda, dealing with targets that were both moving and increasingly particularistic.  If we are not to lose our bearings in this extensive cross-fire of chemical expertise, it is important for us to gain and hold a perspective both as to facts and law.


27
ESE was retained in 1976, after EPA became dissatisfied with the work done over the prior two years by another contractor.  ESE thereafter collected data from pesticide manufacturers and did its own experimentation on samples of waste water, the manufacturers furnishing 95 per cent of the data, and ESE laboratory work accounting for 5 per cent.  The methodology and resulting data used by ESE to identify and quantify organic pesticides relate to two techniques, gas chromatography (GC) and thin layer chromatography (TLC).  The method attracting most of the controversy in this appeal is gas chromatography.  It involves vaporizing a sample of effluent, passing it through a column filled with various materials, which impeded the flow of each compound at a characteristic rate.  Results are recorded on a continuous chart which shows a "peak" when each compound exits the column, thus identifying it in terms of the time it appears, and which indicates concentration by the height and area of the peak.  The method is neither simplistic nor self-executing.  It involves the use of several columns, the testing and calibrating of each with samples containing known quantities of known pesticides, continual checking, and constant alertness for the presence of unforeseen substances which can distort the recording on the strip chart.  The method succeeds only in careful and expert hands.


28
The lore of gas chromatography has been recognized for some time, being the subject of a handbook compiled in 1972 by EPA's Analytical Quality Control Laboratory (and the source of ESE's practices in this rulemaking procedure), the "Analysis of Pesticide Residues . . . " in 1974 and "Analytical Procedures for Pesticides Approved by EPA per 40 C.F.R. Part 136", App.1997-2090.  These compilations dealt with means of isolating interferences (distorting effects occasioned by the presence of unidentified substances), the preparation of apparatus, calibration, reagents, solvents, standard quality control practices, the preparation of samples, extraction, clean-up, and reporting.  Part of the product of ESE's work lay in the development of a new handbook, the Quality Assurance Manual, which was in revision at least through September of 1977.


29
The factors underlying the present controversy as to the methodology of identifying and measuring organic pesticides are threefold: the complexity of the process, the high degree of elimination of pollutants required by the regulations, and the penalties for non-compliance.  33 U.S.C. § 1319.  Petitioners point with dismay to the analytical obstacles, pitfalls, and limitations which EPA acknowledges and warns against,17 and challenge the reliability and adequacy of both GC and TLC.  They further document their dismay by criticizing ESE for lack of an articulated quality control program; criticizing specific instances of ESE's work; noting the wide discrepancies between analyses of the same samples by several manufacturers and by ESE; and challenging the inclusion of a requirement based on chemical oxygen demand (COD) as not being feasible or useful.


30
The considerations governing our task of review in such a case as this have been recently illumined in Weyerhaeuser Co. v. Costle, at 1025, where Judge McGowan, writing for the court, said:


31
"In light of the structure and aims of the Act, and the breadth of authority delegated by it to the EPA to identify highly sophisticated control technology in an area fraught with scientific uncertainty, our review function encounters significant limitations in the substantive aspect where the given statutory standards are 'arbitrary,' 'capricious,' or 'abuse of discretion.'  First, it is elementary that our function is not to weigh De novo the available evidence and to substitute our judgment for that of the Agency.  Second, an expansive concept and exercise of the review power in the eleven Courts of Appeals charged with that function could easily impede accomplishment of the Act's ambitious pollution-ending aspiration as well as its goal of industry-by-industry uniformity.  See generally, Currie, Judicial Review Under Federal Pollution Laws, 62 Iowa L.Rev. 1221, 1261-71 (1977).  This problem looms larger in the substantive area of review than it does in those areas involving statutory interpretation and procedural integrity because of the technological and scientific uncertainty that EPA must overcome as best it can in making the discretionary judgments delegated to it by Congress.  There are also obvious limitations upon the capacity of courts to deal meaningfully with arcane areas of knowledge of this kind."


32
After quoting from the court's earlier opinion in Industrial Union Dep't v. Hodgson, 162 U.S.App.D.C. 331, 338-39 n. 18, 499 F.2d 467, 474-75 n. 18 (1974) ("Where existing methodology or research in a new area of regulation is deficient, the agency necessarily enjoys a broad discretion to attempt to formulate a solution to the best of its ability on the basis of available information."), Judge McGowan summarized the court's view of its mission:"In these circumstances, therefore, we will be content in carrying out our substantive review (that is, assuming the statute and the requisite procedures have been followed), first, to insist upon an explanation of the facts and policy concerns relied on by the Agency in making its decision; second, to see if those facts have some basis in the record; and finally, to decide whether those facts and those legislative considerations by themselves could lead a reasonable person to make the judgment that the Agency has made.  See Citizens to Preserve Overton Park, Inc. v. Volpe, supra, 401 U.S.  (402) at 416, 91 S.Ct. 814, 28 L.Ed.2d 136; Amoco Oil Co. v. EPA, 163 U.S.App.D.C. 162, 180-181, 501 F.2d 722, 740-41 (1974); Industrial Union Dep't v. Hodgson, supra, 162 U.S.App.D.C. 331, at 339-40, 499 F.2d 467, at 475-76."  Weyerhaeuser, at 1026.


33
With these precepts in mind, we consider petitioners' challenges.


34
The first is to the reliability and adequacy of the two basic methods endorsed by EPA, gas chromatography and thin layer chromatography.  Petitioner's general attack is based, as we have noted in note 17, on the acknowledged uncertainties attending the successful use of the methods in dealing with complex mixtures.  It seems to us that EPA's cautions are to be preferred by far to overclaiming or overselling.  It also seems to us that action of this nature, although not without risk to manufacturers, is preferable to no action at all.  We are mindful of the fact that Congress contemplated a certain amount of "technology forcing", Weyerhaeuser, at 1057, expecting EPA "to press sometimes beyond the most advanced technology currently being used".  Id. at 1061.  Here, there is no claim that the technology has not been developed but merely that EPA has overstated its public acceptance.  If the issue were whether the American Society for Testing and Materials (ASTM) and the American Public Health Association (APHA) Had approved GC methods For testing all three classes of organic pesticides for which EPA claims GC to be appropriate, EPA might lose.  But it seems clear to us, from the literature, including the series of manuals and handbooks dealing with both GC and TLC going back at least to 1972, and from the fact that several EPA test methods for organic pesticides have almost completed running the gamut of ASTM and APHA approval processes, that any a priori attack on the methods must fail.


35
This leads us to more specific criticisms.  The most sweeping of these is petitioners' claim that ESE, so far as the record discloses, pursued no systematic and reliable quality control procedures in running its tests on samples of effluent.  In its initial form the argument was that the many steps18 prescribed in the Chemistry Division and Radiochemical Laboratory Quality Assurance Manual, which ESE itself developed, were not followed.  EPA's response, that this Manual was in preparation during most of the time ESE was running its tests, seems sufficient to us.19  Petitioners counter that whether judged by the new Manual or the 1972 Handbook, ESE's procedures were nowhere described or approved by EPA.  This seems to be true.  Were the project for which ESE was engaged that of applying standard technology to routine operations, we might expect to find a pre-established testing procedure.  But here part of the task was to find and develop the appropriate testing technology, resulting in the new Quality Assurance Manual.


36
ESE came on the scene after a prior contractor had been found inadequate.  It obviously had a mandate to produce scientifically acceptable work; EPA had demonstrated its reaction to inadequacy.  Between late 1976 and the fall of 1977 ESE invested 16,500 man hours in this rulemaking process.  (App. 1491) As we have noted, all of its working papers, totalling 2000 pages have been turned over to petitioners.  The specific criticisms we shall later discuss are the total harvest of hindsight.  Most, we think, are answered satisfactorily by EPA; some are ignored.  We find ourselves, as a reviewing court, dealing with adversaries who deal with the issues on different levels.  Petitioners have combed the record to select what they deem to be errors or examples of sloppy work.  EPA, on the other hand, seems to have adopted a rather bland approach, selecting only what it views as important challenges, and giving them a minimum response.


37
The issue of ESE's quality control standards offers an example of these diverse approaches.  Petitioners decry the absence of a description of methods, quality control charts, the failure to prepare a "reproducible standard curve", the failure to run an adequate number of standards, an inadequate number of spiked and "method blank" samples, and duplicate analyses insufficient in quantity and quality.  Their citations to the record are few.  EPA's response to this range of criticism is largely set forth in the following footnote language in its memorandum responding to petitioners' reply brief: "Complaints of inadequate numbers of standard and spiked samples are refuted by laboratory documents supplied petitioners pursuant to the Court's request at argument."


38
We have therefore conducted our own review.  It was restricted to 238 pages of ESE documents (App. 3352-3590).  It was necessarily superficial, since we are not laboratory technicians, since the function of the various forms and entries was often not self evident, and since many of the forms were illegible, some were apparently duplicates (App. 3469, 3470; 3413, 3556) or triplicates (App. 3363, 3474, 3582), and a sizeable number were upside down.  We found frequent evidence that ESE testing had involved the running of duplicates,20 standards,21 blanks,22 and spiked samples.23  Occasionally we found apparently careful step-by-step instructions for performing tests (App. 3352, 3505); notations that a test was defective and ought to be repeated (App. 3476, 3502); remarks that samples had been lost (App. 3414, 3431) or that the recording pen had jiggled in several chromatograms (App. 3412); and interpretive remarks noted in December, 1978, apparently for use of petitioners (App. 3432, 3487-3489, 3491-3492, 3495).  We have also read ESE's monthly progress reports to EPA and see evidence of concern for careful procedure.  (App. 1453, 1455, 1456, 1460, 1461).


39
We cannot be sure that these references are an adequate response to criticisms levied at ESE's general control procedures.  But we cannot play the role of Superchemist.24 Petitioners bear an extremely heavy burden if they desire to demonstrate that the results of a rulemaking procedure are infected with fatal flaws of laboratory practice.  Our review, partial and facial though it is, satisfies us of the probability that EPA was justified in basing its regulation on ESE's work.


40
Our feeling is strengthened by our review of some of the specific instances of alleged error in results charged by petitioners.  They have pointed to the wide divergence of the analyses conducted principally by manufacturers Rhom and Haas and Eli Lilly and those performed by ESE on "split" samples of the same waste water.  ESE consistently found much higher quantities of pesticide in the samples.  As we have indicated above, we have not found sufficient reason to reject ESE's analytical procedures or results.  And, while the methods generally used by the companies were sufficiently reliable,25 we know nothing of the procedures actually used by the companies in taking and preserving these samples.  We therefore cannot say that the divergence of results indicates error on the part of ESE.  Moreover, of course, rejection of the lower figures is to the ultimate advantage of the companies, increasing the allowable discharge.


41
Petitioners also focused on what first appeared to them as a "patent error" in ESE's calculations of the amount of waste water used in a test, amounting to more than a 55 gallon drum.  But this turned out to be correct, EPA saying that the sample was so polluted that it had to be diluted 250,000 times.  Petitioners noted two strip charts for sample 9010, speculating that a "shoulder" indicated interference and that a peak which ran off the paper could not be only 3.6 centimeters high.  But EPA counters by saying the first peak was so pesticide-laden that it did indeed run off the paper, but that the Rerun was indeed 3.6 centimeters high.  The supposed interference denoted by the shoulder was the occasion for the technician's comment we have noted concerning the jiggling of the recorder pen.  App. 3412.  Other charges were that two strip charts supposedly representing duplicate analyses were not "remotely comparable" the response being that they were successive analyses with the differences due to the large amount of pesticide present in the early extractions; that ESE improperly used higher influent numbers ascertained by a Perkin-Elmer instrument with no explanation for rejecting the lower numbers obtained by a Varian instrument the reply being that each instrument is more effective in different ranges of numbers.  Although petitioners have a retort in each such instance, we must say that EPA clearly has the better of these arguments.


42
There are other even more minor issues where we confess that we are not sure of the winner whether as to a particular analysis, a standard strip chart should have been verified, whether ESE's injections were too little in volume, whether the lack of confirmatory tests on alternate columns of different polarity was significant.  As to these and other issues, EPA either did not respond or did not do so at sufficient length to be understandable.  But we have said enough to indicate that residual doubt on issues of increasing minuteness is far from sufficient to cause us to interpose a different judgment than that exercised by the Agency in choosing to rely on its contractor.


43
Petitioners have raised one additional issue of a substantive technical nature in challenging EPA's choice of COD as a parameter.  The contention is that it serves no purpose where wastes possessing large amounts of salts are to be dealt with.  Diamond Shamrock's data are said to be of doubtful validity.  But without such data, leaving only that developed by Monsanto's Muscatine and Anniston plants, the standard would be even more stringent.  Wholly apart from absence of prejudice, EPA points to the wide use of COD in industry as a measure of long term biochemical oxygen demand and a comment from Olin that "(I)t is a mystery why the Agency feels compelled to establish a limitation on BOD when COD measurements are more feasible."  C.App. 212.26  We cannot, in the words of the court in Weyerhaeuser, slip op. at 23, say that "a reasonable person (could not) make the judgment that the Agency has made."


44
C. EPA's Determination of Best Practicable Control Technology Currently Available


45
Even accepting the work of ESE as accurate, petitioners argue that the results do not support EPA's conclusion that carbon adsorption and hydrolysis are effective technologies for pre-treating pesticide waste streams to remove organic pesticide chemicals.  Closely related to this challenge are the arguments that the numbers with which EPA calculated the final effluent limits were inaccurate, thus invalidating those limits, and that EPA could not reasonably combine all manufacturers of organic pesticides into one category required to meet the same limits.  EPA's decision that by using the model technology, including either carbon adsorption or hydrolysis, all plants achieved "similar" pesticide content in their effluent led EPA to conclude "that the waste waters of all organic pesticide chemicals can be treated or controlled to the levels documented in the Agency's data base."  43 Fed.Reg. 17777 (1978).


46
In carbon adsorption, the organic molecules reach the surface of the carbon where they diffuse into the carbon's porous structure and bind with the carbon.  The molecular structure and solubility of the pesticide influence its adsorption characteristics.  Periodically the carbon becomes saturated and requires regeneration which can be accomplished by incineration.  The resulting flue gases are quenched, scrubbed, and discharged to the atmosphere.  The carbon can then be reused, although its adsorptive capacity will be somewhat reduced.


47
Hydrolysis is a chemical process in which the pesticide compounds are broken down by adding a caustic (or an acid) to the waste water setting off a reaction with the water and the organic compounds.  The hydroxyl or hydrogen ions attach to some part of the pesticide chemical molecule, either displacing part of the group or breaking a bond so that two or more new compounds form.  The success of hydrolysis is a function of the temperature and pH (relative acidity or alkalinity) of the solution and the properties of the chemical.  Some compounds hydrolyze relatively easily compared to others.  The ability of a compound to be hydrolyzed can be measured in terms of the half-life of the reaction, the time it takes at a given temperature and pH to hydrolyze half the chemical present.  The shorter the half-life, the easier it is to destroy the pesticide through hydrolysis.


48
The regulations do not require the use of any particular treatment technology so long as the effluent limitations are met.  One of the premises of the regulations, however, is that by using either carbon adsorption or hydrolysis, together with equalization and biological treatment, any plant could meet the regulations.  Petitioners argue that there is no basis for this conclusion and that, therefore, we should remand the regulations as to the organic pesticides category.  They suggest that the data collected at operating facilities are unrepresentative, inaccurate, and insufficient to demonstrate that those facilities achieve the results EPA claims; that even if those facilities do achieve the results claimed there is no data to suggest other plants producing other pesticides could achieve comparable results; and that EPA's references to literature and pilot studies fail to support its conclusion.


49
We emphasize again that our review of agency rule-making is very limited, especially where the Agency must overcome technological and scientific uncertainty in making its delegated discretionary decisions.  See Weyerhaeuser, at 1025.  We will not remand so long as the Agency has explained the facts and policies on which it relied; the facts have some basis in the record; and a reasonable person could make the judgment the Agency made.  Id. at 1026.  Thus, the petitioners carry an extremely heavy burden when petitioning for review in such a case as this.


50
EPA identified eight full-scale carbon treatment systems used to reduce pesticides and five full-scale hydrolysis systems.  The Agency sought information on all these facilities.  One of the plants using carbon adsorption (one of the petitioners before us) disclosed neither the operating conditions of the system nor individual analyses of its effectiveness.  Information on the remaining 12 systems is presented in great detail in section VII of the Development Document.  Five of the seven carbon systems achieve removal rates in excess of 99 per cent of the influent pesticide as do two of the three hydrolysis systems for which data is available as to the pesticide content of both the influent and effluent of the treatment system.  The two hydrolysis systems, for which only effluent data is available reduced the pesticide level to less than 1 mg/1 (one part per million) and to below the detection point respectively.  EPA has concluded that the two substandard carbon systems and one sub-standard hydrolysis system could all achieve much better results by adjusting the operating conditions of the facilities (replacing the carbon more often or holding the waste water in the treatment system for a longer period).


51
Petitioners attack the use of data from the carbon systems because the systems were not designed to remove pesticides.  This attack is trivial.  EPA faces a severe problem in regulating the pesticide industry because a great deal is not known about treatment of pesticide waste waters and because the industry is very reticent about revealing what it does (or could) know.  Given this admitted information shortage EPA must make use of the information it has, recognizing the limits of the information; EPA cannot refuse to carry out its mandate, waiting for the day when it might possess perfect information.27  Whatever reasons industry might have had for installing carbon treatment systems, if those systems are effective at removing pesticides then EPA can and should make use of that information.  The alternative would be to ignore the mandate of the Federal Water Pollution Control Act and allow the pesticide industry to develop treatment systems at its own pace, releasing information about those systems only for the purposes and under the conditions the industry might see fit.  Congress has rejected that alternative.


52
The same answer applies to petitioners' claim that the data on carbon treatment systems were too sparse to support any conclusion about their effectiveness.  EPA had no more than 25 observations at any given facility and as few as 4 observations at another.  EPA used all the data it could accumulate.  Had the industry come forward with more data there is every indication that EPA would have used it.  Data on the performance of the treatment systems are entirely within the control of the industry.  We will not hear industry complain that EPA used insufficient data when industry was uncooperative in supplying the missing data.  It was up to EPA to decide whether the limited data base was sufficient to support the conclusions reached.  We hold that deciding to base conclusions on the limited data available was a reasonable exercise of discretion given the regulatory mandate.28


53
Petitioners suggest that even the limited data available at three of the carbon treatment plants are unrepresentative because the data were collected too soon after replacement of the carbon columns or because some wastes bypassed the treatment system being studied.  The sampling at Eli Lilly covered the first 4 days of a 7 day carbon cycle.  The record does not reveal why the carbon was changed just before sampling began or whether either ESE or Lilly timed the change purposely.  The data, however, covered more than half the cycle, and the record reveals that the results obtained during the ESE sampling period were, if anything, unrepresentative on the high side since they showed a higher concentration of pesticide in the treatment effluent than the company found in its own studies.  C.App. 217.  The sampling at Hardwicke was done early in that company's normal 30 day carbon cycle, but, as EPA noted, the carbon should be changed far more frequently and the sampling was fairly representative of what would have been a reasonable carbon cycle for the plant.


54
Petitioners also argue that Lilly and Olin generated waste streams containing pesticides that did not pass through the treatment systems.  Their citations with regard to Lilly are unconvincing.  The direct communication from Lilly says nothing about a pesticide-bearing waste stream by-passing carbon treatment.  The MITRE study does not support the claim.  It says that the only two waste sources containing the pesticide may be combined prior to treatment.  C.App. 206.  We find no indication that the "Floor drains, Cooling waters, and Miscellaneous Waste Streams" contained any pesticide.  C.App. 207.


55
The problem with respect to Olin is not so easily disposed of.  On March 15, 1977, Olin submitted its comments on the interim final regulations.  It stated that EPA's data omitted "supplementary waste streams containing some process waste waters."  C.App. 213A.  An attachment to these comments described the supplementary waste streams as including "among other things, spills, wash-downs, vent scrubber effluents, and surface runoff.  In this wastestream, the following waste by-product streams are not included: 1. PCNB Plant Hydrochloric Acid; 2. PCNB Plant Spent Sulfuric Acid; 3. TCAN Plant Hydrocholoric Acid."  C.App. 213A.  Finally, this letter stated as "basically an intelligent guess" that 1.3 pounds of pesticide were in the supplementary waste stream (not including "TCAN, HCL, PCNB HCL and PCNB spent nitration acid.").  EPA visited Olin's plant on August 17, 1977.  According to a memorandum of that visit, "(p)lant personnel were unable to provide back-up information supporting the revised waste load estimates reported to EPA in a letter from Olin dated March 15, 1977.  They agreed to provide the basis of these revised waste loads upon receipt of a letter from EPA."  C.App. 304.  On August 18, 1977, EPA sent a letter to Olin seeking, inter alia, more information about the supplementary waste streams; confirmation that "these supplementary waste streams have not been, and are not currently being treated by activated carbon, but rather are neutralized and discharged"; and confirmation that the existing "waste byproduct streams" (the acid streams) were being reused or sold.  App. 2625-26.  Olin answered by letter of September 14 that it had no additional data on raw waste load (other than some flow rate data); that "(t)he supplementary waste streams associated with the PCNB Plant are currently only being neutralized"; and that "(t)he information you have outlined for the current disposition of the three by-product acid streams is correct."  C.App. 352-53.


56
EPA's response to petitioners' argument is that "(t)he truth as acknowledged by Olin, is that there are no (unaccounted for) streams."  EPA brief at 62.  EPA's brief-writers misread the exchange quoted above.  They interpreted Olin's acknowledgement that the three acid by-product streams were not being discharged as meaning that no supplementary waste streams were being discharged.  A clear distinction was made at all times in the exchange of correspondence between the acid "by-product waste streams" and the pesticide-bearing supplementary waste stream.  The latter is clearly the one of concern, and Olin clearly stated that it was being discharged with no treatment other than neutralization.


57
The implication is that Olin was discharging more pounds of pesticide per thousand pounds of production than the figure EPA used in calculating the limits, and, therefore, the limits were miscalculated and should be corrected.29  The treatment given the issue in EPA's brief leaves us uncertain how to handle it.  On the one hand, we might be inclined to discount an "intelligent guess" about extra pesticide when no supportive data is forthcoming despite the Agency's follow up efforts.  On the other hand, though, EPA has not explained the basis for ignoring the new information, and EPA's brief deals with it on an inaccurate basis.30  Under these circumstances we feel compelled to remand the regulations for consideration of petitioners' claim that the Olin data should not be used in calculating the final effluent limits.  It may be that EPA can easily correct any defect, but we must put them to the task.


58
Similar arguments are directed against plants EPA used to illustrate hydrolysis treatment.  Petitioners object to reliance on two plants claiming that in fact neither has an hydrolysis system.  In fact the record reveals that both plants hydrolyze the wastes, albeit not in separate hydrolysis basins.  Kerr-McGee adds a caustic to elevate the pH above 11 and elevates the temperature to facilitate the reaction.  App. 991.  Monsanto's Anniston plant similarly sets off a reaction with addition of caustic to raise the pH, App. 2459, though the temperature is not raised.  App. 126-27.  In effect, hydrolysis and biological treatment occur simultaneously.  Although there may be some problem in attributing the destruction of the pesticide to one or the other cause, both treatments are recommended, and the success of these systems is relevant to whether companies can meet the guideline limits31 and supports the conclusion that hydrolysis is being used successfully in the industry.  The same holds true for Shell's Axis plant.  Though there is no influent data, the effluent data indicates that with the hydrolysis system the discharge of pesticide can be reduced below the detection point.


59
Petitioners argue that even the plants for which EPA has operating data are far from "similar" since, for instance, their pesticide output varies between 0.0000765 and 0.00315 kg/kkg.  This is indeed a rather broad range, but it does not disturb us.  The Act imposes no obligation on EPA to subdivide industries so that each point-source category contains identical producers.  The development document reveals that EPA carefully thought about the relevant factors when it divided the pesticide industry into three categories.  App. 57-61.  It had tried to subdivide the organic pesticides into three subcategories, and that attempt was shown to fail.  In fact, as we have noted, industry commenters demonstrated that those three subcategories were indistinguishable from each other and that that subcategorization scheme was inequitable.  After further study EPA concluded that there was no reason to use subcategories at all.  The advantages would be negligible since there were no clear dividing lines between groups of manufacturers, and the disadvantages, as pointed out by the industry, were significant.  Under the circumstances we cannot say it was unreasonable for EPA to reject industry's advice that the fewer than 30 direct dischargers of organic pesticides be divided into more than one category.  Certainly we see no congressional mandate that this industry be further subcategorized.


60
Having decided to use a single category, EPA had to set the limits for it.  Its decision to use only data from full-scale operating systems and to ignore zero-discharge plants was well within its discretion.  Thus it needed a way to express the limitation more precisely than a requirement such as that all plants "do as well as the plants we have surveyed".  It needed to express the results of the survey data as a number typical of the model group that is, an average.  Averaging the effluent data from the model plants is very different from averaging apples and oranges or bananas and marshmallows.  If the plants performed identically, no average would be necessary.  Though the plants performed differently, even very differently, we cannot see why averaging is unacceptable.  The same parameter was measured in the same way and in the same units.  The set of observations thus derived made up the population of which an average was desired.  The problem, as we see it, was not whether an average could be taken, but how to derive that average.32


61
EPA chose to calculate a weighted average that gave equal influence to each observation rather than to each plant.  Thus the plant with 4 observations had far less influence on the final average than the plant with 450 observations, but each observation at the two plants had exactly the same influence.  We are sure there were many alternatives to this system, but we cannot say that EPA went beyond its discretion in picking this one.  We agree with the Fourth Circuit that "the choice of statistical methods is a matter best left to the sound discretion of the Administrator."  FMC Corp. v. Train,539 F.2d 973, 986 (4th Cir. 1976); American Petroleum Institute v. EPA,540 F.2d 1023, 1035 (10th Cir. 1976).  The choice of any given method may mean that an alternative method would yield different results.  The necessary corollary, however, is that any other system chosen would be open to the same criticism.  We will not leave the Agency so vulnerable.


62
Even if the plants studied demonstrate that carbon or hydrolysis treatment is effective for the pesticides they produce, petitioners point out that they produce only a small minority of the 49 pesticides whose discharge is controlled.  This is true, but it hardly means that the regulations must be limited to those pesticides for which EPA has collected information on operating treatment systems or even to the larger group of pesticides currently being treated by adsorption or hydrolysis.33  There is literature data which suggests that other pesticides are amenable to treatment.  See note 27, Supra.  Also, the Agency is entitled to use its chemical expertise to conclude that compounds' manufacturing processes, chemical structures, and physical properties are sufficiently related so that if one is treatable the others are likely to be as well.34  Certainty is not required.  It is enough that the EPA has considered the problem and that the petitioners have failed to convince us that the conclusion is unreasonable.35  Petitioners have presented no evidence that any particular regulated pesticide is not amenable to treatment.  Moreover, we assume that if any plant had evidence that an adequate, properly run treatment facility corresponding to EPA's recommendations could not achieve the guideline limits, the plant would have a strong case that it is "fundamentally different" and entitled to less stringent limitations.  40 C.F.R. § 455.22, 43 Fed.Reg. 17780 (1978).  We conclude, with the one reservation expressed above, that the Agency has demonstrated that hydrolysis and carbon adsorption are currently used, effective pesticide treatment techniques; that the Agency permissibly decided that the techniques are broadly applicable to facilities manufacturing the 49 pesticides discharge of which is regulated; and that it was within the Agency's authority to require all manufacturers of organic, non-metallo pesticides to meet the same effluent limitations.

D. EPA's Consideration of Cost

63
The Act requires EPA's assessment of best practicable control technology currently available to "include consideration of the total cost of application of technology in relation to the effluent reduction benefits to be achieved."   33 U.S.C. § 1314(b)(1)(B).  Cost, however, is not a paramount consideration.  Congress "self-consciously made the legislative determination that the health and safety gains that achievement of the Act's aspirations would bring to future generations will in some cases outweigh the economic dislocation it causes to the present generation."  Weyerhaeuser, at 1037.  The obligation the Act imposes on EPA is only to perform a limited cost-benefit balancing to make sure that costs are not "wholly out of proportion" to the benefits achieved.  A Legislative History of the Water Pollution Control Act Amendments of 1972 170 (1973) (statement of Senator Muskie); Weyerhaeuser, at 1045 n. 52.  Thus, the balancing is a relatively subsidiary task and need not be precise.36  Weyerhaeuser, at 1049.  The Agency has considerable discretion to decide how to go about considering costs and benefits and need not "perform the elaborate task of calculating incremental balances" of marginal costs and benefits.37  Id.


64
We are satisfied that EPA has done an acceptable job in this case.  Facing a highly diverse industry, and struggling with an admitted dearth of information (for which not without some justification it blames the industry), EPA sought to determine on a plant-by-plant basis the capital and operating costs each plant would incur in meeting the effluent limits.  EPA found only seven direct dischargers that would incur additional costs.38  Of these, EPA predicted five faced increased annual costs equal to only 0.2 to 2.0 per cent of revenues from pesticide chemicals and would not change employment or production.  A comparable estimate could not be made for one other, and the last one would face costs of 3.6 per cent of revenues.  EPA concluded that the latter two might experience reduced profitability but would continue in production.  Capital costs were expected to total $9.9 million and annual costs $5.1 million for the industry.  43 Fed.Reg. 17777-78 (1978).


65
The Agency based these estimates on model treatment techniques assuming a variety of plant sizes and treatment difficulties.  The petitioners criticize the estimates and their application to plants on a variety of grounds.  Though many of the criticisms may be valid, suggesting that the estimates are not perfectly accurate, none of them convince us that EPA's evaluation of costs must be rejected.  There is no way the cost analysis could be more than an estimate, especially given the reticence of the industry to supply information, and EPA needed to develop no more than a rough idea of the costs the industry would incur.  On the basis of its estimates, EPA decided to promulgate these regulations.  We cannot say that the Agency has failed to consider costs in relation to benefits, and we find no basis on which to overrule EPA and decide that costs are wholly out of proportion to benefits.

II. Metallo-Organic Pesticide Manufacturing

66
Subpart B of the regulations is "applicable to discharges resulting from the manufacture of metallo-organic active ingredients containing mercury, cadmium, arsenic, or copper."  40 C.F.R. § 455.30; 43 Fed.Reg. 17786-87 (1978).39  The regulations forbid any discharge of process waste water pollutants to navigable waters.  40 C.F.R. § 455.32.  The only challenge is from one of the three manufacturers of arsenic-based pesticides, Diamond Shamrock.  Diamond Shamrock alleges that its process requires it to discharge arsenic contaminated waste water and that the record fails to support EPA's conclusion that a process with no discharge is the best practicable control technology currently available.


67
Diamond Shamrock has twice in the past reported that its arsenic manufacturing process had no discharge of polluted waste water.  In August, 1975, it reported to EPA that its "process has a negative water balance (and is) able to utilize essentially all, including rainwater from the process area, in the product."  A 1972 report stated, "The arsenical unit has no discharge its design is such as to recycle all waters into the final product."  Other reports, however, are either ambiguous or assert that Diamond Shamrock in fact discharges contaminated waste water.  A 1974 study reported, "Diamond Shamrock's plant is a 'low effluent' plant, although they do discharge aqueous waste.  . . .  (T)he discharge of arsenic averages about 0.7-0.8 (parts per million).  . . .  The total amount of arsenic discharged amounts to only about 1/2 lb per day."40  In July and August, 1977, Diamond Shamrock told EPA and ESE during a meeting and during an inspection of the plant that it discharged waste water and could not meet the limit in the interim regulations.  Data covering January through May of 1977 show that there is arsenic in the waste water discharged from the arsenic process to the biological treatment facility and in the discharge from the treatment facility.  Flow charts describing Diamond Shamrock's production process show that waste water can be recycled, but suggest that some is not.  Finally, ESE's notes of an April 26, 1976, telephone conversation between an ESE researcher and a Diamond Shamrock plant manager reveal that the plant manager admitted that arsenate production has no waste but also said the plant could not meet a limit of 0.1 parts per million.41


68
Though the record is far from clear, it indicates to us that, while Diamond Shamrock may once have been a non-discharger, at least as of the time these regulations were promulgated the plant was discharging pollutants and had so advised EPA.  This does not, however, end the inquiry.  The fact remains that the other eight manufacturers in the metallo-organic subpart, including the two other producers of arsenic pesticides, achieve zero discharge and have not joined the petition for review,42 and Diamond Shamrock held itself out as a non-discharger on some occasions.


69
Diamond Shamrock's attempts to refute EPA's evidence concerning the other plants are unpersuasive.  The evidence consists of notes of phone conversations between ESE and officials at the other two arsenic plants, Vineland and Ansul.  According to the notes, Vineland's chief chemist claimed all waste water is recycled to the process, and the Ansul official said, "All wastewater from the pesticide production is reused in the process; the only discharge is of non-contaminated cooling water."  Though transcribed notes of phone calls are not the best possible evidence, it seems that EPA confronted stern industry resistance in its attempts to put together a more reliable data base.  Industry cannot be allowed to profit from the success of its resistance to regulatory inspections.  Moreover, in proceedings such as these EPA has to be able to rely on industry-supplied information, especially where dishonesty would be counter-productive for the informants.


70
It appears that the industry can and does produce arsenic-based pesticides without discharging polluted waste water.  The statute, though, requires more; EPA must consider specific factors including "the total cost of application of technology in relation to the effluent reduction benefits to be achieved . . . , and . . .  the process employed, the engineering aspects of the application of various types of control techniques, process changes, (and) non-water quality environmental impact . . . ."  33 U.S.C. § 1314(b)(1)(B).  EPA's excuse for not considering these factors is that Diamond Shamrock does not now, or at least did not in the past, discharge polluted waste water, therefore it would not have to change its process or incur any costs in meeting the regulations.43


71
The record as we construe it does not support EPA's reasoning.  Diamond Shamrock is now a discharger.  It will have to change something, whether in its production process or its treatment process, in order to meet the regulation.  EPA must give some consideration to the cost and impact, if any, of implementing these changes and compare the cost to the reduction benefits.  Until it has performed that task, EPA has not discharged its statutory responsibilities.  Having failed to consider the relevant factors, EPA abused its discretion, and we must remand.


72
As indicated in our discussion of the required cost analysis above, the consideration may be general, and EPA has considerable discretion to determine the scope of the investigation.  We also emphasize that our remand on this issue is a limited one to give EPA an opportunity to perform the statutorily mandated assignment.  If EPA discovers that in fact Diamond Shamrock will not incur costs or that the benefits of the regulation are not wholly out of proportion to the costs to the industry, then we will be prepared to uphold the regulations as written.

III. Formulators and Packagers Subcategory

73
Subpart C of the regulations apply to formulators and packagers of pesticides.  40 C.F.R. §§ 455.40-455.42.  This segment of the industry, encompassing approximately 5300 companies, mixes technical grade pesticide chemicals with inert ingredients by dry-based, solvent-based, or liquid-based processes to produce usable commercial products.  These companies are required to release "no discharge of process waste water pollutants to navigable waters".  40 C.F.R. § 455.42.  EPA expects them to meet this limit by a combination of in-process controls and collection and evaporation of whatever waste water cannot be avoided.  NACA, on behalf of the formulators and packagers, has intervened in these petitions for review to challenge the no discharge limitation on a number of grounds.  NACA argues that EPA's data base is so inconsistent, inaccurate, and incomplete that it cannot support any conclusion and that even taking the data base at face value it does not support the conclusion EPA has reached.  Further, NACA argues that EPA has failed to meet the statutory mandate to consider certain factors.  33 U.S.C. § 1314(b)(1) (B).


74
We agree with NACA that EPA's treatment of this industry segment is not a model of administrative regulatory methodology, but, nonetheless, we find sufficient reliable data in the record to support EPA's conclusion that zero discharge is the best practicable control technology currently available for this category.  We rest this conclusion on two sources of data with respect to the reliability and value of which EPA and NACA nearly agree.44  The first of these is a telephone survey conducted by ESE.  ESE polled, at random, a segment of the industry,45 and compiled 47 responses.46  Of these 47, only 3 discharge process waste water pollutants into navigable waters.  Another 8 discharge waste water to privately operated treatment facilities, but such discharges would not run afoul of these regulations.47  Thus, 94 per cent of the companies currently can comply with these regulations, and 77 per cent are not discharging any process waste water at all.


75
These results are confirmed by the second source, a report compiled by a contractor hired by NACA and submitted to EPA by NACA.  The report's conclusions included the following:


76
"Some plants are currently operating with no discharge of process waste water.  By conservative water usage and improved housekeeping practices, most plants can either eliminate or significantly reduce the volume of process waste water generated."


77
"The best practicable control technology currently available for most plants in the industry appears to be an evaporative system having no effluent.  For those plants that cannot effect complete evaporation of their process waste water, partial evaporation in conjunction with disposal in an approved landfill appears to be the best alternative."48


78
This study contacted 105 companies, getting 91 usable responses.  Of these 91, 66 discharged no waste water.  Only 5 discharged directly to navigable waters, and another 20 discharged to private treatment facilities or practiced deep well injection or ocean dumping.  Thus 73 per cent of the companies have no discharge at all, and 95 per cent comply with these regulations.  The results are virtually identical to ESE's results.  Whatever the failings of these studies, the numbers clearly show that the great majority of formulators already meet the limitations, and it follows that meeting the regulations is practicable for the industry looked at as a whole.


79
NACA does not seriously dispute that conclusion.  Rather NACA suggests that we should not rely on the numbers at all and that the category should not be looked at as a whole.  NACA attacks the methodology of the ESE survey because two different survey forms were used, those were not completely filled out, the results have been inconsistently reported, and the survey failed to generate any information on the effectiveness of any pre-discharge waste water treatment systems.  Neither we nor EPA rely on this survey for anything beyond the information that was collected the company's formulating process and whether or not it generated or discharged process waste water.  That other questions were not asked or answered is for this purpose irrelevant.  Similarly, that the survey results have been inconsistently reported is of no matter so long as the final tabulation is accurate.  NACA challenges the survey it submitted because that survey was not designed to serve the purpose for which EPA used it, was hastily done, and left many questions unanswered.  Again, our use of it, like EPA's, is only for the results it did collect, not for whatever it may have failed to determine.


80
NACA next suggests that the formulating category should have been broken into two subcategories because EPA's first contractor, Weston, so recommended and because it is "obvious . . .  that formulators whose very operations involve the use of water and other liquids will generate wastewater and cannot achieve zero discharge."  EPA was in no way bound to accept its contractor's suggestion.  Our inquiry is only whether the solution EPA did adopt is rational and supported by the record.


81
The ESE survey collected information on the type of process used as well as waste generation and discharge.49  The survey does not support NACA's assertion that plants using water-based processes inevitably must discharge process waste water.  Of the 47 responding facilities, 20 produce liquid-based pesticides.  Of these 20, only 2 run afoul of these regulations by discharging process waste water directly to navigable waters.  An addition 8 facilities discharge waste water to private treatment facilities.  Half the liquid-based formulators have no discharge at all.  These numbers clearly show that even formulators using liquid-based processes can and do achieve zero discharge.


82
Given EPA's supported finding on the basis of the survey that the industry in large part achieved zero discharge, EPA did not need to go through the further steps of designating some number of these plants "exemplary" and averaging the zero discharge reports of the exemplary plants to set a zero discharge limit for the subcategory.  To be sure, it might have been well for EPA to visit some of the facilities reporting zero discharge in order to verify the reports, but at some point EPA must be able to rely on information provided by industry, and here the companies had no incentive to report discharges below actual levels, thereby inviting regulations they could not meet.


83
We turn now to the factors the statute mandates that EPA consider.  In particular, NACA argues that EPA has failed adequately to consider "non-water quality environmental impact" and "the total cost of application of technology in relation to the effluent reduction benefits to be achieved."  33 U.S.C. § 1314(b)(1)(B).


84
As we have said, the cost/benefit comparison mandated by Congress is "intended to limit the application of technology only where the additional degree of effluent reduction is wholly out of proportion to the costs of achieving such marginal level of reduction for any class or category of sources."  Legislative History, Supra, at 170; Weyerhaeuser, at 1045 & n. 52.  Congress did not intend cost to be an unwieldy barrier to attainment of pollution control goals.  We have already explained the nature of our review.


85
EPA devoted significant effort to discovering the economic impact of these regulations on the formulating and packaging segment of the industry.  Not only did EPA attempt to find out the number of companies that would have to incur new costs to comply with the regulations, but it also prepared estimates of the cost of compliance on the assumption that small, medium, and large plants would have to build evaporation treatment systems from scratch.  NACA attacks these cost estimates on two fronts.  The first is that EPA failed to consider adequately or accurately the cost of hauling waste water or sludge remaining after evaporation to a landfill.  EPA's estimates are only for evaporation systems, not the alternative acceptable technology of hauling all waste water to a landfill.  But evaporation is the more expensive of the two alternatives.50  Therefore, there was no reason to consider hauling separately.  EPA further asserts that the cost of hauling the sludge left after evaporation is included in its assessment of annual "operating/maintenance" costs for the evaporation system.51  Though it might have been well for EPA to provide a more detailed itemization of its cost estimates, given the limited scope of our review, we will not impose any such mandatory duty.  We have no basis on which to doubt the EPA's assertion in this regard.


86
NACA's second attack is that EPA used unrealistic estimates of evaporation rates.  EPA used the median evaporation rate for the country in developing its estimates.  NACA recognizes this by saying that the figure used "overestimates the annual evaporation rate for approximately half the nation" and "over half the pesticide formulation plants".  EPA is entitled to look at costs on an industry-wide basis as opposed to plant-by-plant.  To do so EPA must be able to make some assumption about the conditions facing the industry.  Certainly, using an appropriately chosen average figure is a legitimate statistical technique, especially given that EPA is doing no more than developing rough estimates to help it determine whether the cost "is wholly out of proportion" to the benefit.  Moreover, EPA notes that the evaporation tank volumes allotted are more than ample to accommodate the very slow build up of waste water that might accumulate where evaporation is significantly less than the national average.  This build up can be hauled periodically to landfills.


87
Given EPA's determination that the cost of installing and operating an evaporation system would be acceptable even for a plant that starts with no system at all and that most formulators already comply with the regulations, EPA gave ample consideration to the comparison of cost with benefit.  To be sure, the record contained only scanty data on the quantity of pollutants in formulators' waste water.52  On the other hand, EPA has discovered that the cost of compliance for the industry is small.  Any discharges that trigger a requirement for a company to incur new costs must bear some pollutants, or they would not be illegal.  Therefore, eliminating those discharges will produce benefits.  This seems to be the implicit logic of the Agency, and we find it persuasive.  It is rational to conclude that the small costs to the industry are not wholly out of proportion to the benefits.  We must remember that the goal of the Act is to eliminate discharges of pollutants into navigable waters, and this effluent limitation accomplishes that goal.


88
The Agency must also "take into account . . .  non-water quality environmental impact".  The District of Columbia Circuit has held that this means the Agency must inform itself of the magnitude of potential problems and reach an "express and considered conclusion about their bearing".  Weyerhaeuser, at 1045.  The Agency has done so, though in a most cursory way.  43 Fed.Reg. 17776, 17780 (1978).  The Agency noted that the major problem would be sludge and concentrated waste disposal.  Though there is no specific finding of the magnitude of the problem and no express statement of conclusions, it is clear that EPA considered the problems and decided they were not of sufficient magnitude to prevent promulgation of these regulations.  The Agency noted that it has published guidelines on solid waste disposal, 40 C.F.R. Part 241, and that it is in the process of developing regulations under the Resource Conservation and Recovery Act of 1976, 42 U.S.C. §§ 6901 Et seq., to regulate hazardous wastes.53  We infer that EPA concluded that waste disposal can be accomplished at an acceptable cost to the environment.  As to air pollution EPA asserts in its brief that the Resource Conservation and Recovery Act regulations will deal with air pollution associated with disposal of hazardous waste.  Though no detailed study appears in the record, the record reveals that EPA was aware of the problem, did not consider it significant, and felt that, where necessary, treatment could prevent air pollution.  App. 1233.  "(S)ince Congress intended EPA's internal structure to protect the non-water environment, the judicial function is completed when we have assured ourselves that EPA expressly considered the probable environmental impacts of its regulations."  Weyerhaeuser, at 1053.


89
Finally, NACA challenges EPA's decision that plants which both manufacture and formulate pesticides must meet the limits for manufacturing plants with no credit for any discharge from the formulation process.  NACA suggests that this will force combination plants to separate their waste streams because if combined the manufacturer will have to treat the waste water to levels better than those attained by BPT.  As EPA points out though, most formulation processes do not generate or discharge waste water, including many at plants that also manufacture pesticides.  Also, waste flows from formulation, where they exist, will be very small compared to the flow from manufacturing.  As a consequence any burden on combined plants choosing to treat wastes together should be minimal.  If that assumption proves wrong, of course, the plant retains the option of keeping the formulation waste separate and evaporating it or hauling it to a landfill.  It seems eminently reasonable to us that if formulation plants are required to attain zero discharge, they should not be able to discharge extra pollutants simply because they happen also to manufacture pesticides.


90
Because of the minor problems noted above, the regulations must be remanded.  We have no reason to believe that either of the reasons for this remand the misunderstanding concerning one company's reporting of the waste content of its discharges and the Agency's failure to consider the possible costs of implementing the regulations in the metallo-organic subcategory will pose a serious stumbling block to final approval of the regulations.  Accordingly we will retain jurisdiction over these consolidated petitions for review so that we can bring a speedy conclusion to this case once the Agency has set the record straight and made whatever corrections it deems necessary.

So ordered.54


*
 Of the District of Massachusetts, sitting by designation


1
 The petitioners are BASF Wyandotte Corp., Diamond Shamrock Corp., FMC Corp., Olin Corp., American Cyanamid, Union Carbide Corp., E. I. duPont de Nemours & Co., Inc., Ciba-Geigy Corp., Monsanto Co., Dow Chemical Co., and Eli Lilly and Co


2
 For a more thorough discussion of the statutory framework See Weyerhaeuser Co. v. Costle, 590 F.2d 1011, 1019-1021 (D.C. Cir. 1978), and cases cited


3
 The interim regulations limited the phenol and ammonia content of discharges from some pesticide production plants.  41 Fed.Reg. 48088 (1976)


4
 In the words of the Attorney General's Manual on the Administrative Procedure Act (1947), a contemporary explanation of the Act's purposes and provisions, "the notice should be sufficiently informative to assure interested persons an opportunity to participate intelligently in the rule making process."  Id. at 30.  Even where the Agency could publish the proposed rule itself, the Manual suggests that it may choose not to, issuing instead "a more general 'description of the subjects and issues involved.' "  Id. at 29


5
 The interim regulations included separate subcategories for manufacturers of Halogenated Organic Pesticides, Organo-Phosphorous Pesticides, and Organo-Nitrogen Pesticides


6
 Respondent incorrectly read petitioners' procedural challenge as being limited to this change.  BASF petitioners' brief clearly states other alleged deficiencies in notice:
"EPA should have exposed to public comment its decision to limit the regulations to those pesticides for which there are reliable analytical methods, its decision to adopt a single category for all organic pesticides, its determination that all pesticides can be treated to a single level regardless of differences in treatability of particular pesticides and its assessment of the applicability and effectiveness of carbon treatment and hydrolysis."


7
 See, e. g., Comments of Mobay Chemical Corp., App. at 1753


8
 Id., App. at 1772


9
 Mobay, for instance, expressed its concern that the interim limitations "for the organo-phosphorus subcategory were based on prejudiced and . . .  inequitable treatment when compared to the halogenated organics and organo-compounds (sic)."  App. at 1755


10
 For an example, see the comments of E. I. duPont de Nemours & Co., App. at 1915


11
 It is ironic that petitioners should be attacking EPA's use of an expanded data base since a constant theme of their substantive attack on the regulations has been that EPA did not collect enough data to support the regulations


12
 One of these plants, able to meet the limits without all the components of a recommended treatment system, was not explicitly relied on in developing the interim limit, but was mentioned as supporting the reasonableness of the limit set


13
 The purpose of requiring notice is to generate responses as well as to hold agencies to adequate procedures.  Where petitioners do not take advantage of chances to influence the agency we must look with less favor on those petitioners' allegations of inadequacy in the result.  See Weyerhaeuser, at 1028 n. 15


14
 To help illustrate, we think it apparent that had EPA made a serious arithmetical error in calculating the interim regulations so that the effluent limits were higher than they should have been if correctly figured, EPA would have been privileged to make the correction between proposal and final promulgation without submitting the revision for new comment


15
 This case differs from Weyerhaeuser, at 1028-1031, because the Agency's final published explanation fully accounts for the limits set.  There are no undisclosed numbers or factors on which the Agency must rely to support its final limits.  See id. at 1030.  The same calculations on the same factors were used for both the interim and final regulation, although the factors' values varied


16
 Petitioners also complain about data from new plants being used to generate the final BOD and COD limits, but this was evidently because they misidentified one of the plants.  In any case, substantially the same plants supplied the data for both the interim and final regulations


17
 The introductory material in "Analytical Procedures" describing the application of gas chromatography to organochlorine pesticides contains such language as: "Under favorable circumstances, Strobane, toxaphene, chlordane (tech.) and others may also be determined"; "The usefulness of the method for other specific pesticides must be demonstrated by the analyst before any attempt is made to apply it to sample analysis"; when there are "complex mixtures, the individual compounds may be difficult to distinguish . . . .  Provisions incorporated in this method are intended to minimize the occurrences of such interference"; "the method offers several analytical alternatives, dependent on the analyst's assessment of the nature and extent of interferences and/or the complexity of the pesticide mixtures found"; "This method is recommended for use only by experienced pesticide analysts or under the close supervision of such qualified persons"; "It is not possible to describe procedures for overcoming all of the interferences that may be encountered in industrial effluents."


18
 These included a complete description in final project reports of methods used, a pre-established quality assurance plan for each project, the use of quality control input sheets and instrument log books, determination of maximum times for holding samples, documentation of ways in which samples were selected, calibration of instruments, frequent preparation of "linearity curves", frequent running of standards to keep track of changes on the performance of the equipment, and routine checks through running a blank (solvent extracted from distilled water) through the column, conducting duplicate analyses of the same waste water sample, and running "spiked" samples (waste water to which known quantities of pesticides have been added)


19
 Petitioners point out that tests of one manufacturer, Olin, were not completed until after the Manual was fully revised.  Their argument that failure of ESE to jettison its prior procedures and follow the newly promulgated Manual in conducting the very last tests on one plant's samples constitutes adequate basis for remand seems to us utterly unrealistic


20
 Vol. 10, App. 3353, 3356, 3363, 3382, 3426, 3439, 3460, 3469, 3470, 3473, 3484, 3485, 3490, 3493, 3494, 3498, 3499, 3501, 3515, 3516, 3518, 3520, 3521, 3523, 3565, 3566, 3567, 3582, 3590


21
 App. 3355, 3382, 3388, 3433, 3490, 3493, 3500, 3501, 3502, 3503, 3514, 3515, 3517, 3527


22
 App. 3520, 3522, 3523, 3448, 3450, 3454, 3476, 3493, 3494, 3498, 3500


23
 App. 3439, 3460, 3472, 3473, 3475, 3476, 3565


24
 Here is an example of thrust and parry between chemists where we are being asked to give the final answer
Petitioners: ESE did not run duplicates for 4 or 5 plants relied on.  (Main brief, p. 46)
EPA: It did, at all 4, citing appendix references.  (Main brief, p. 56, n. 64)
Petitioners: But for duplicate samples to provide quality control over extraction and clean-up techniques, the duplicate samples must be independently extracted, cleaned up, and injected into the column.  (Reply brief, p. 18)
EPA: But the samples were so laden with pesticide, that they had to be preserved in chloroform; this meant that when a sample container was opened, the whole sample would have to be used immediately.  Hence ESE could run only injection duplicates.  (Memorandum in response to petitioners' reply brief, p. 6)
Petitioners: No.  The layering that might be induced by chloroform could be avoided by mixing the sample just prior to splitting.  Moreover, the need to preserve the sample arose because of ESE's excessive delay.  Also, ESE's alleged method does not provide for the use of chloroform.  Also, the lab notes say nothing about the need to shortcut making parallel extractions.  (Memorandum in response to EPA memorandum, p. 4)


25
 As EPA noted in 43 Fed.Reg. 17776, 17781 (1978):
"The analytical procedures utilized by each manufacturer were solicited by EPA and evaluated by the Environmental Monitoring and Support Laboratory in Cincinnati.  The data utilized in establishing these limitations were derived from analytical methods which, in the opinion of the Cincinnati Laboratory, 'appear capable of measuring the compound with adequate sensitivity.' "


26
 References to the confidential portion of the appendix will be to "C.App."


27
 By the same token, petitioners' broadbased attack on EPA's use of data in literature must be rejected out of hand.  Certainly the literature data are not as valuable as operating plant data would be, but the plants have not supplied enough information, and the literature is useful for what it does say.  For instance, if the literature identifies a particular pesticide as amenable to treatment by adsorption or hydrolysis under laboratory conditions, that does not guarantee the same results under industrial conditions, but neither does that mean the information should be ignored.  It means that, other things being equal, the pesticide can be treated.  It is then up to the Agency experts to decide whether relaxing the laboratory conditions would so change the result that the pesticide could not be treated by industry.  Merely attacking the literature because it is experimental is no help to petitioners' cause unless they can also show that the particular conclusions drawn from the literature are unreasonable.  We have found nothing in the Act to outlaw scientific deductive reasoning


28
 EPA took account of the limited data at some plants by using a weighted average that gave relatively less weight to facilities from which it had fewer observations in the calculations of the final effluent limitations


29
 This confusion cannot impugn the conclusion that Olin's carbon adsorption system effectively treats the waste streams that in fact pass through it


30
 The brief-writers compound the inaccuracy (and diminish our trust in them) by arguing that the 1.3 pound figure must be disbelieved because it disagrees with data submitted by Olin on September 14, 1977.  C.App. 353.  That data only concerned the influent and effluent of the carbon adsorption system.  The 1.3 pound figure related to waste not passing through the system


31
 Petitioners also object to use of data from Hercules to calculate the effluent limits.  Hercules uses neither hydrolysis nor carbon adsorption to treat its waste water.  It achieves excellent results with a physical-chemical system relying on equalization ponds, gravity separation, and neutralization.  Though it does not support the proposition that hydrolysis and carbon adsorption are common industry techniques, it is evidence of the levels to which pesticides can be reduced by treatment.  There is no reason to ignore these results simply because they are achieved more easily than by use of the recommended model technology


32
 The statistical methodology used in the interim regulations was fully disclosed and was the subject of extensive comment.  In response to those comments EPA revised its methodology


33
 The industry failed to supply data on some operating systems


34
 By a combination of these sources and extensions of information, EPA explicitly reached conclusions as to all but 10 of the 49 pesticides.  App. 111, 113, 118-119, 126, 128-131, 132, and 138.  The ten of which we find no mention are BHC, Dichloran, Mirex, Barban, Fenuron, Fenuron TCA, Swep, Dicamba, Silvex, and Perthane.  We are willing to assume from EPA's general language that it reached similar conclusions as to these ten pesticides as well


35
 There is every indication that EPA was fully aware of the various factors that, as petitioners point out, can affect the relative amenability to treatment of different pesticides.  The development document mentions them.  See, e. g., App. 104, 110, 120.  We will not assume that the Agency failed to take account of such factors when it evaluated the possibility of extending the recommended treatment techniques to other chemicals


36
 We are not convinced that the duty to "include consideration of cost in relation to benefit" imposed on EPA by this clause of § 1314(b)(1)(B) is significantly different from the duty imposed by the same subsection to "take into account" certain other factors.  But see Weyerhaeuser, at 1045-1046.  We see no more reason for us to substitute our judgment for the EPA's concerning costs and benefits, assuming that the Agency has "informed itself as to their magnitude, and reached its own express and considered (opinion)", See id., than concerning the other enumerated factors


37
 We agree with the Weyerhaeuser court that "when an incremental analysis has been performed by industry and submitted to EPA, it is worthy of scrutiny by the Agency."  At 1048.  duPont's study, indicating rapidly increasing costs for removal of incremental amounts of pollutants, certainly was "worthy of scrutiny", and we assume that EPA did not ignore it.  Largely through no fault of duPont's, however, the study tested a carbon adsorption model very different from the one that formed the basis for EPA's cost estimates.  Most notably, duPont studied contact times of 22, 44, and 66 minutes whereas EPA prepared cost estimates for systems with contact times of 60, 300, 600, and 750 minutes.  Generally the longer the effluent remains in contact with the carbon, the more efficient the treatment will be.  We are not prepared to say that the duPont study demonstrates that incremental costs of EPA's model system were wholly out of proportion to incremental benefits, nor will we require EPA explicitly to respond to every study submitted by commenters


38
 EPA lacked information as to two others.  The Agency, in a permissible exercise of discretion, did not consider costs already incurred in complying with NPDES discharge permits.  Weyerhaeuser, at 1049


39
 " 'Metallo-organic active ingredients' means carbon containing active ingredients containing one or more metallic atoms in the structure."  40 C.F.R. § 455.31(a)


40
 This study apparently formed the basis for a 1975 EPA report which, however, made a most critical error in transcription.  It said, "Diamond Shamrock's plant is a 'low effluent' plant, although aqueous waste is Not discharged.  . . .  (T)he discharge of arsenic averages about 0.7 to 0.8 (parts per million).  The total amount of arsenic discharged amounts to only about 1/2 lb/day."  (Emphasis added.)  The internal inconsistency is obvious


41
 Diamond Shamrock's comments on the interim development document expressed concern about the zero discharge limit, but on the ground that there is a higher permissible level for arsenic in public water supplies


42
 One of the other arsenic producers, Ansul, has apparently ceased production.  Its performance while in operation, however, is relevant in determining achievable discharge limitations


43
 The Development Document reports as follows:
"No cost estimates have been developed for this subcategory.  The state-of-the-art at plants manufacturing metallo-organic pesticide chemicals is no discharge of process waste water pollutants.  It was originally reported that all plants were no 'discharge' facilities, however, representatives of one facility (plant 19) recently indicated that there is a discharge from their manufacture of metallic-organo pesticide chemicals.  This is being investigated by the Agency.  The overall impact to this subcategory is expected to be minimal."  App. 166.
EPA now advises us that there is not any on-going investigation.


44
 EPA also relied on an "Economic Analysis of Effluent Limitations Guidelines for the Pesticide Chemicals Manufacturing Point Source Category", a 1975 report entitled "Pollution Control Technology for Pesticide Formulators and Packagers" together with the telephone survey on which it was in part based, and a study of one company with 38 facilities.  There is no suggestion that these studies conflict with the two we will discuss; rather, NACA argues that they are unreliable, irrelevant, or not applicable to all companies


45
 The exact number of firms contacted is not clear from the record before us which reveals only the firms which responded to the survey.  It may be that this distinction between contacts and responses accounts for the confusion reported in note 46, Infra.  NACA has not challenged, and indeed has relied upon, the random nature of this survey


46
 EPA has reported the number surveyed to be as high as 100.  NACA suggests the number of relevant responses may be as low as 40.  No matter how NACA shuffles the data, however, the basic conclusion on which we rely comes forward.  The great majority of formulating companies do not discharge any process waste water pollutants into navigable waters


47
 If, as NACA asserts, future regulations outlaw these indirect discharges, NACA may challenge those regulations.  We cannot overturn regulations because companies able to comply with them might be unable to comply with supposed future rules


48
 NACA notes that this conclusion is tempered by the word "appears" and by the qualification that air pollution problems that may be connected with evaporation should be studied


49
 For four of the companies no process is indicated.  We shall assume that the one of these which did discharge waste water used a water-based process and that the other three used dry-based processes.  This puts the uncertain data in the light most favorable to NACA


50
 This is true even if NACA's figure for the cost of contract hauling is substituted for EPA's.  EPA assumed hauling would cost $5 per gallon and that hauling all waste water would, therefore, cost about $4600 per year for a medium size plant, about half the $9100 annual operating cost of an evaporation system.  Using the $8.50 per gallon cost suggested by NACA, the annual cost for the same plant would go up to about $7800, still significantly less than the cost of the evaporation system


51
 Again, even if EPA used the wrong price for contract hauling, See note 50, Supra, its analysis would not be significantly in error.  Operating maintenance costs comprise a very small percentage of the total annual operating costs, and, we assume, hauling costs are less than all the operating costs.  Even if All the operating costs were for hauling, the $8.50 price would increase total operating cost by only $700 for the medium plant, raising the total annual cost to about $9800, an increase of only about 8% Which would in turn increase the estimated cost per gallon at the medium plant from $0.073 per gallon to $0.079 per gallon


52
 Weston did compile some information on the basis of literature, company data, and plant visits.  App. 1711


53
 We need not concern ourselves at this time with the additional economic cost, if any, to the pesticide industry of future compliance with these regulations.  EPA can more properly consider such costs in proceedings concerning those regulations.  Any attempt to assess the costs of compliance with unpromulgated regulations would be premature and highly speculative.  We know of no law that prohibits an agency from attacking the evils within its jurisdiction in a piece-meal fashion.  A contrary rule would make the regulatory process unworkable


54
 We do not reach any issues raised exclusively by Mobay Chemical Corp. in Nos. 77-1081 and 78-1223.  Action on those petitions is being withheld so that counsel for Mobay and EPA may pursue efforts to settle their disputes


